Cancer ache production mechanism

Mechanism which (cancer pain) produces about cancer ache, at present thought that has three ways, namely: Cancer develops the result ache, diagnoses and the ache which as well as cancer patient the treat cancer causes infects the ache which concurrently, constant pain disease and cancer ache syndrome occurs. In these three ways, 75%~80% patients are because the tumor invasion soft tissue, the marrow as well as the nervous system cause, 15%~20% are produces in cancer's diagnosis and the course of treatment, 5%~10% pieces are because has merged ache disease. First, cancer develops the result ache 1st, cancer infringement Nervous tissue cancer cell through axilemma around lymph road or along nerve around resistivity weak spot infiltration, then again to nerve axis cylinder invasion. Cancer infringement nerve causes the ache has three reasons:① In the axilemma nerve fiber is infiltrated the strangulation result;② The cancer cell releases certain sends the painful material, like 5- hydroxy colorsThe amine, slow stirs up functions and so on peptide, histamin to cause the ache in the peripheral nerve;③ Trophic nerve's blood vessel is stopped up by the cancer cell, the nerve fiber is at the ischemia condition to cause the ache. On clinical, the metastasis has the stubborn ache, often appears by neuralgia's form, its nature is the sharp pain, often diffuses to the body surface innervation scope. When the cancer lump infiltrates to the abdominal cavity nerve plexus, the mesentery nerve plexus, the shinbone nerve plexus, the ache spot becomes not explicitly, the ache assumes the endurance. 2nd, outside the hard membrane shifts, the spinal cord to oppress outside the hard membrane the shift is breast cancer, the prostate gland cancer, the lung cancer, the multiple myeloma, malignant melanoma, the kidney cancer's common complication. Outside the hard membrane shifts when the cancer oppresses the spinal cord, ache limitation in cone, close median line. When tumor infringement nerve root, then presents the nerve root to distribute the region the sharp pain or the stabbing pain, the ache assumes the belt-shaped distribution, if does not treat, then may have the spinal cord oppression syndrome, is accompanied by the feeling, the movement, the nervus autonomici change or the barrier. 3rd, when the cancer infringement lumen internal organs malignant tumor causes the lumen internal organs function barrier, may have the ache, its characteristic is not explicit localization, periodic and the repeatable outbreak, often is accompanied by disgusting, the vomit, the distension of the abdomen. The biliary duct, the pancreatic duct narrow or blocking often causes the intense ache; The carcinoma of uterus, the ovarian cancer oppression and infringement ureter may also cause the hard to endure colic. 4th, cancer infringement vascular system cancer lump oppression, the jamming or infiltrate when the artery, the vein, the lymph vessel may cause the ache. 5th, regardless of cancer infringement skeleton is the primary bone tumor or the transferability bone tumor, may have the hard to endure ache. 6th, cancer itself secretes sends the painful material cancer cell necrosis disintegration to release the tumor necrosis factor, the prostaglandin, 5- hydroxy tryptamines, slow to stir up the peptide, the histamin and so on to send the painful material to cause the ache. Second, after cancer diagnosis and treatment, causes ache 1st, the diagnosis inspection causes the ache marrow puts on attracts the biopsy technique, the lumbar vertebra puncture method, wound and so on each kind of endoscopy inspections, may give the cancer patient to bring the ache. 2nd, after surgical operation, after the ache surgical operation damages the nerve as well as the technique, the scar forms the small neuroma to be possible to cause the ache; After the technique, the scar luan shrinks pulls pulls, the cancer lump recrudescence to pull pulls the organization to be possible to have the ache. 3rd, after radiotherapy, the ache radiotherapy may cause the organization to have the fibrosis, the oppression or pulls pulls the nerve and the ache sensitive organization has the ache. After common radiotherapy, the ache syndrome has the radioactive nerve plexus to get sick with the radioactive myelopathy. In addition, after the radiotherapy, produces the mycodermatitis, dermatitis, the enteritis, the belt-shaped herpes, the radioactive pneumonia and so on may cause the ache the occurrence. 4th, after chemotherapy, time ache chemotherapy venipuncture; After hepatic artery irrigation chemotherapy and abdominal cavity chemotherapy, causes proliferating abdominal pain; After the chemotherapy, causes phlebitis, mycodermatitis, enteritis, hemorrhagic cystitis; As well as the chemotherapy medicine's poisonous side effect causes polyneuritis and so on. 5th, after involvement treatment, ache each kind (for example puts on after the skin internal organs puncture method after Pi Gan, after Pi Shenchuan and so on); Moves the venipuncture after the skin to set at the tube technique and so on has creates the involvement treatment technology, may have the ache. 6th, after hormone treatment, after ache hormone treatment, the ache is called the steroid pseudo rheumatism, is refers to the cancer patient after accepting the sugar cortical hormone treatment, the whole body muscle, the tendon, the joint and the bone have the cauterization type ache, specially the intercostal muscle has the saccadic ache, simultaneously accompanies the general malaise, soft and weak and gives off heat, sometimes is also accompanied by the psychology and the dysphrenia. 7th, after immunity treatment, after ache common immunity treatment, causes the ache refers to the acute ache which the interferon causes, this kind of ache performance to give off heat, the shiver, myodynia, the arthralgia and the headache. 8th, after analgesia treatment ache cancer ache patient in analgesia course of treatment, may also have the new ache. The intramuscular injection and the hypodermic injection analgesic may cause the ache; Some patients after use meconium class medicine, may have the repeatable entire headache and so on. Third, merge infection, constant pain disease as well as cancer ache syndrome 1st, cancer merge infection causes the ache malignant tumor patient is extremely easy to be accompanied by the ache concurrently the infection, this kind of infection often by the bacterium, the fungus or the virus causes. 2nd, cancer merge constant pain disease cancer merge constant pain disease is refers to the cancer patient simultaneously to contract each kind of arthritis, the fascutis, cervical vertebra sickness, the waist intervertebral disc prominently sickness and so on. 3rd, cancer merge cancer ache syndrome cancer merge cancer ache syndrome is refers to cancer patient to have cancer ache syndrome concurrently, invades and the spot, the organizational structure difference according to the tumor, appears has certain characteristic ache. Generally the treatment relative difficulty, needs the complex therapy. 4th, the psychological factor urges cancer patient ache degree aggravating as well as a hindrance cancer ache treatment result substantial clause is the psychological factor influence, mainly includes: Restless, angry, despondent and so on three kind of psychological factors.