Cancer painful pharmacological treatment three steps and ladders therapy

The cancer pain is one serious symptom merely, its basic principle of reatment should be treats the symptoms and the causes, namely treats the cancer pain to take stopgap measures, treats cancer to effect a permanent cure, takes stopgap measures to effect a permanent cure provides the optimum condition, the two supplementary can have the better treatment result. In cancer pain treatment's each method, the pharmacological treatment is most basic, is most effective, the most commonly used method. Especially the early mild cancer painful patient should use the pharmacological treatment. Because the pharmacological treatment has, the function to be rapid effectively, the risk is small, expense reasonable and so on merits. The basic principle defers to the special details formulation individual therapeutic schedule. Before choice pharmacological treatment ache symptom or other symptoms, must determine that causes the ache specific reason, the appraisal ache intensity and the nature, then chooses the medication again. The pain-relieving should the dosage plan and the non-wound treatment method starts from the simple, and close observation treatment result. Treats the cancer pain to have three broad heading medicines:①Must from body class anti-SARS analgesia medicine namely common analgesic;②Meconium class analgesic;③Auxiliary analgesic, sedative and trophic nerve medicine and so on. the l. mild cancer pain may endure generally, can the normal life, the sleep basic not receive disturbs, should defer to the first steps and ladders treatment. The first steps and ladders treatment is in principle the oral administration must from the body class anti-SARS analgesic, this kind of analgesic function in the end, has allays a fever the analgesia anti-SARS effect, can suppress the hypothalamic prostaglandin synzyme the production, reduces prostaglandin E the synthesis and the release, shifts patient's ache to the prostaglandin content high bone to be effective. Has the aspirin, the paracetamol on behalf of the medicine, to hold his forest and so on. The aspirin start dosage is 250-500 mg/time, most large dose 1000 mg/time, the every 4- 6 h heavy clothing applies drugs one time, then serves the analgetic purpose. The paracetamol takes orally 1 time0.3- 0.6 g/time, 0.6- 1.8 g/d, the treatment course is not easy to surpass 10 d. Holds his forest to take orally 25 mg, daily 3 or suppositories 50mg/time, daily 2 times. Should also replace the medicine type frequently in the treatment, like disperses the pain, the cloth Luo river fragrance, the profuse cloth fragrance superiorly and so on, reduces the gastro-intestinal tract complication and the untoward effect. 2. the moderate cancer pain often was the long-enduring ache, the sleep has received the disturbance, the appetite has the decrease. This kind of ache patient must apply the analgesia medicine, but applies drugs should adopt in principle gradually to the second steps and ladders transition principle, namely while gives must from body class anti-SARS analgesic, gives the analgesic auxiliary, like Qu Maduo or weak effect meconium class analgesic, like codein, dextrorotary third oxygen fragrance and so on. In the evening may take the tranquilizer and the sleeping draught and so on. The pain overcomes is one kind must allays a fever the new medicine from the body class force pain-relieving and the moderate anti-SARS, is mainly through suppresses the prostaglandin the synthesis, may with the opium receptor union, not have the addictive nature. 30 mg pains overcome the analgetic function to be equal to the 12mg morphine, it uses in the moderate cancer painful curative effect good medicine. The strong pain decides (AP-237) to have the effect quick merit, is suitable in the moderate cancer painful patient. 3. the specific weight or the unendurable fierce ache sleep and the diet receive the significant disturbance, in the evening the human rests the difficulty, the ache aggravating. This time with common analgesic already basic invalid, has eased the pain the function with other analgesics or the weak effect meconium class analgesic. The specific weight fierce ache should by the second steps and ladders to the third steps and ladders treatment transition, use the strong effect meconium class analgesic regularly, what at present the mouth takes medicine is commonly used is US executes Kangting (i.e. morphine to control releases piece), each piece including morphine 30 mg, each time the l-2 piece, every 12 h takes orally one time, if cannot take orally time, may pass through the anus to give the medicine. Other strong effect meconium class analgesic has the morphine, the hydrochloric acid dihydro etorphine, US to disperse the alkone left, pai for ding, Fentaini, Uncle Ding Fei, Ding Bingnuo fei, nan and so on. The analgesia for the morphine alkanes synthetic drugs, the excited k opium receptor oppresses the anti-U opium receptor newly, to breathes suppresses weakly, the dependence is small, the analgesia intensity for morphine l/4- l/3, may take for a long time, oral administration each time 25-50 mg, when necessity every 3-4 h takes 1 time. The World Health Organization designs simply, effective, the recognition, the reasonable steps and ladders therapy to be possible to enable 90% cancer patient's ache to obtain the effective alleviation, 75% above terminal cancer patient ache can relieve. When pharmacological treatment should pay attention to the following 5 requests, namely oral administration, on time, according to steps and ladders, individual difference medication. Attention nuts and bolts.