Gives the analgetic medicine on time to the cancer patient, is must defer to the medicine the response time, stipulated the time-gap gives the medicine, but is not only in the patient ache time only then gives the analgetic medicine. The reason is as follows: 1st, after first for medicine, requires certain time to be able to achieve the effective blood medicine density, particularly controls releases (slow release) the medicine, if the morphine sulphate controls releases the piece to be able to achieve the effective blood medicine density for the medicine latter 1 hour. In this “blank time”, if for the fast-acting medicine, the patient still do not endure the ache. 2nd, the ache often is accompanied by the mood, the psychological change, after the ache appears, only then gives the pain-killer, often needs to give compared to a maintenance pain greater dose cannot achieve analgetic the goal. 3rd, when patient ache only then the line stops pain, often needs to give the fast-acting analgetic medicine, but so gives the meconium class medicine often to cause the blood medicine density intense large fluctuation, increases the untoward effect. Therefore, should choose the persistent effect to control as far as possible releases the dosage-form like morphine sulphate to control releases the piece (US to execute Kangting) and so on, gives the medicine on time, but is not on demand gives the medicine, like this can guarantee that maintenance effective, steady blood medicine density, guaranteed that the ache alleviates continually, and is not easy to have the energetic dependence.
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